Mechanical mechanisms of chromosome segregation
Chromosome segregation—the partitioning of genetic material into two daughter cells—is
one of the most crucial processes in cell division. In all Eukaryotes, chromosome …
one of the most crucial processes in cell division. In all Eukaryotes, chromosome …
Physical bioenergetics: Energy fluxes, budgets, and constraints in cells
Cells are the basic units of all living matter which harness the flow of energy to drive the
processes of life. While the biochemical networks involved in energy transduction are well …
processes of life. While the biochemical networks involved in energy transduction are well …
Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus
The large-scale organization of the genome inside the cell nucleus is critical for the cell's
function. Chromatin—the functional form of DNA in cells—serves as a template for active …
function. Chromatin—the functional form of DNA in cells—serves as a template for active …
Lessons on the force-form-function connection in cell biology from modeling a syncytial germline
Germline architecture plays a critical role in the production of functional gametes. Across
species, oogenesis involves not only the preparation of the genome for sexual reproduction …
species, oogenesis involves not only the preparation of the genome for sexual reproduction …
Self-organization of kinetochore-fibers in human mitotic spindles
During eukaryotic cell division, chromosomes are linked to microtubules (MTs) in the spindle
by a macromolecular complex called the kinetochore. The bound kinetochore microtubules …
by a macromolecular complex called the kinetochore. The bound kinetochore microtubules …
Engineering stability, longevity, and miscibility of microtubule-based active fluids
P Chandrakar, J Berezney, B Lemma, B Hishamunda… - Soft Matter, 2022 - pubs.rsc.org
Microtubule-based active matter provides insight into the self-organization of motile
interacting constituents. We describe several formulations of microtubule-based 3D active …
interacting constituents. We describe several formulations of microtubule-based 3D active …
Inapparent infections shape the transmission heterogeneity of dengue
Transmission heterogeneity, whereby a disproportionate fraction of pathogen transmission
events result from a small number of individuals or geographic locations, is an inherent …
events result from a small number of individuals or geographic locations, is an inherent …
Computational studies reveal how passive cross-linkers regulate anaphase spindle elongation
Y Wang, YR Liu, PY Wang, P **e - The Journal of Physical …, 2024 - ACS Publications
In eukaryotic cell division, a series of events are organized to produce two daughter cells.
The spindle elongation in anaphase B is essential for providing enough space to maintain …
The spindle elongation in anaphase B is essential for providing enough space to maintain …
Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors
Microtubules and molecular motors are essential components of the cellular cytoskeleton,
driving fundamental processes in vivo, including chromosome segregation and cargo …
driving fundamental processes in vivo, including chromosome segregation and cargo …
Effects of microtubule length and crowding on active microtubule network organization
Active filament networks can organize into various dynamic architectures driven by cross-
linking motors. Densities and kinetic properties of motors and microtubules have been …
linking motors. Densities and kinetic properties of motors and microtubules have been …