Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management

M Berk, O Köhler‐Forsberg, M Turner… - World …, 2023 - Wiley Online Library
Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Ultra-processed food, reward system and childhood obesity

V Calcaterra, H Cena, V Rossi, S Santero, A Bianchi… - Children, 2023 - mdpi.com
Obesity and overweight are a major public health problem globally. Diet quality is critical for
proper child development, and an unhealthy diet is a preventable risk factor for …

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

K Timper, JC Brüning - Disease models & mechanisms, 2017 - journals.biologists.com
The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects

G Milos, J Antel, LK Kaufmann, N Barth, A Koller… - Translational …, 2020 - nature.com
To examine the hypothesis that normalization of low circulating leptin levels in patients with
anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity …

Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring

AH **ang, X Wang, MP Martinez, D Getahun… - Diabetes …, 2018 - diabetesjournals.org
OBJECTIVE To examine the relative importance of maternal preexisting type 1 diabetes
(T1D), preexisting type 2 diabetes (T2D), and gestational diabetes mellitus (GDM) on risk of …

Brain signaling systems in the type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases

AO Shpakov, KV Derkach, LM Berstein - Future science OA, 2015 - Taylor & Francis
The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

Diabetes, a contemporary risk for Parkinson's disease: epidemiological and cellular evidences

D Sergi, J Renaud, N Simola… - Frontiers in aging …, 2019 - frontiersin.org
Diabetes mellitus (DM), a group of diseases characterized by defective glucose metabolism,
is the most widespread metabolic disorder affecting over 400 million adults worldwide. This …

Brain and behavioral correlates of insulin resistance in youth with depression and obesity

MK Singh, SM Leslie, MM Packer, YV Zaiko… - Hormones and …, 2019 - Elsevier
Depression, together with insulin resistance, is increasingly prevalent among youth. These
conditions have traditionally been compartmentalized, but recent evidence suggests that a …

Activity-based anorexia animal model: a review of the main neurobiological findings

S Spadini, M Ferro, J Lamanna, A Malgaroli - Journal of Eating Disorders, 2021 - Springer
Background The genesis of anorexia nervosa (AN), a severe eating disorder with a
pervasive effect on many brain functions such as attention, emotions, reward processing …

The sedentary (r) evolution: Have we lost our metabolic flexibility?

J Freese, RJ Klement, B Ruiz-Núñez… - …, 2018 - pmc.ncbi.nlm.nih.gov
During the course of evolution, up until the agricultural revolution, environmental fluctuations
forced the human species to develop a flexible metabolism in order to adapt its energy …