The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Endothelial function assessment by flow-mediated dilation method: a valuable tool in the evaluation of the cardiovascular system

S Mućka, M Miodońska, GK Jakubiak… - International journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) in the course of atherosclerosis are one of the most critical
public health problems in the world. Endothelial cells synthesize numerous biologically …

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant

H Guo, X Yu, Y Liu, DT Paik, JM Justesen… - Science translational …, 2023 - science.org
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …

Morphological and functional remodeling of vascular endothelium in cardiovascular diseases

G Bkaily, D Jacques - International Journal of Molecular Sciences, 2023 - mdpi.com
The vascular endothelium plays a vital role during embryogenesis and aging and is a cell
monolayer that lines the blood vessels. The immune system recognizes the endothelium as …

The role of the cell surface glycocalyx in drug delivery to and through the endothelium

L Fu, HN Kim, JD Sterling, SM Baker… - Advanced Drug Delivery …, 2022 - Elsevier
Cell membranes are key interfaces where materials engineering meets biology. Traditionally
regarded as just the location of receptors regulating the uptake of molecules, we now know …

Regeneration and assessment of the endothelial glycocalyx to address cardiovascular disease

S Banerjee, JG Mwangi, TK Stanley… - Industrial & …, 2021 - ACS Publications
Endothelial cell (EC) glycocalyx (GCX) loss permits blood circulating particle infiltration of
the vessel walls and leads to vascular dysfunction, atherosclerosis, and serious downstream …

Microvascular leakage as therapeutic target for ischemia and reperfusion injury

JA Kloka, B Friedrichson, P Wülfroth, R Henning… - Cells, 2023 - mdpi.com
Reperfusion injury is a very common complication of various indicated therapies such as the
re-opening of vessels in the myocardium or brain as well as reflow in hemodynamic …

Effects of dietary-based weight loss interventions on biomarkers of endothelial function: a systematic review and meta-analysis

R Mathur, Z Ahmid, AW Ashor, O Shannon… - European journal of …, 2023 - nature.com
Endothelial dysfunction is closely linked to the development of atherosclerosis. This
systematic review and meta-analysis reviewed the evidence on the effect of weight loss …

The effects of folic acid supplementation on endothelial function in adults: a systematic review and dose-response meta-analysis of randomized controlled trials

M Zamani, F Rezaiian, S Saadati, K Naseri… - Nutrition journal, 2023 - Springer
Background Endothelial dysfunction serves as an early marker for the risk of cardiovascular
disease (CVD); therefore, it is an attractive site of therapeutic interventions to reduce the risk …

Agri-food waste from apple, pear, and sugar beet as a source of protective bioactive molecules for endothelial dysfunction and its major complications

C Caliceti, M Malaguti, L Marracino, MC Barbalace… - Antioxidants, 2022 - mdpi.com
Endothelial damage is recognized as the initial step that precedes several cardiovascular
diseases (CVD), such as atherosclerosis, hypertension, and coronary artery disease. It has …