Low-grade gliomas cause considerable morbidity and most will recur after initial therapy. At
recurrence, low-grade gliomas can undergo transformation to high-grade gliomas (grade III …

Abstract Purpose of Review Low-grade gliomas (LGG) are a group of primary brain tumors
that arise from supporting glial cells. They are characterized by a mutation in the isocitrate …

To follow the revision of the fourth edition of WHO classification and the recent progress on
the management of diffuse gliomas, the joint guideline committee of Chinese Glioma …

The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …

OBJECTIVE This is the first clinical outcomes report of NRG Oncology RTOG 0539, detailing
the primary endpoint, 3-year progression-free survival (PFS), compared with a predefined …

Brainstem gliomas are molecularly heterogeneous diseases, many of which are difficult to
safely surgically resect and have limited treatment options due to their eloquent location …

Importance The initial report of NRG Oncology/Radiation Therapy Oncology Group (RTOG)
0424 demonstrated a 3-year overall survival benefit with the addition of temozolomide to …

The management of diffuse supratentorial WHO grade II glioma remains a challenge
because of the infiltrative nature of the tumor, which precludes curative therapy after total or …

Neoplasms of the central nervous system (CNS) are the most frequently encountered solid
tumors of childhood, but are less common in adolescents and young adults (AYA), aged 15 …

Background Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-
2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 …