Synaptic AMPA receptor composition in development, plasticity and disease

JM Henley, KA Wilkinson - Nature Reviews Neuroscience, 2016 - nature.com
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

The dynamic synapse

D Choquet, A Triller - Neuron, 2013 - cell.com
The constant dynamic movement of synapses and their components has emerged in the last
decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein …

Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95

D Nair, E Hosy, JD Petersen, A Constals… - Journal of …, 2013 - jneurosci.org
The spatiotemporal organization of neurotransmitter receptors in postsynaptic membranes is
a fundamental determinant of synaptic transmission and information processing by the brain …

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

TE Chater, Y Goda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

Balance and stability of synaptic structures during synaptic plasticity

D Meyer, T Bonhoeffer, V Scheuss - Neuron, 2014 - cell.com
Subsynaptic structures such as bouton, active zone, postsynaptic density (PSD) and
dendritic spine, are highly correlated in their dimensions and also correlate with synapse …

Regulation of AMPA receptor trafficking and synaptic plasticity

V Anggono, RL Huganir - Current opinion in neurobiology, 2012 - Elsevier
AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …

Molecular mechanisms of early and late LTP

SB Baltaci, R Mogulkoc, AK Baltaci - Neurochemical research, 2019 - Springer
LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …

Actin in dendritic spines: connecting dynamics to function

P Hotulainen, CC Hoogenraad - Journal of Cell Biology, 2010 - rupress.org
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing …

[HTML][HTML] Functional organization of postsynaptic glutamate receptors

N Scheefhals, HD MacGillavry - Molecular and Cellular Neuroscience, 2018 - Elsevier
Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

Synaptic signaling in learning and memory

MB Kennedy - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Learning and memory require the formation of new neural networks in the brain. A key
mechanism underlying this process is synaptic plasticity at excitatory synapses, which …