Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic
cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent …

Introduction Ferroptosis is an iron-dependent regulated necrosis and has been proven to
contribute to the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid …

The amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that
functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …

Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …

Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Acute infections are associated with a set of stereotypic behavioral responses, including
anorexia, lethargy, and social withdrawal. Although these so-called sickness behaviors are …