Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …

Background The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-
TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring …

Exercise can improve cognitive function and has been linked to the increased expression of
brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms …

The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays
a central role in a regulatory network governing the transcriptional control of mitochondrial …

Background Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs
of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial
biogenesis and function. Some of these factors act exclusively within the mitochondria to …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

In multicellular organisms, the ability to regulate reproduction, development, and nutrient
utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that …