Disordered eating is often associated with marked psychological and emotional distress,
and severe adverse impact on quality of life. Several factors can influence eating behavior …

In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous
physical activity (SPA), as lesion or stimulation of this region alters these behaviors …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …

Overeating ranges in severity from casual overindulgence to an overwhelming drive to
consume certain foods. At its most extreme, overeating can manifest as clinical diagnoses …

Background There are sex differences in addiction behaviors. To develop a pre-clinical
animal model to investigate this, the present study examined sex differences in sucrose …

Ghrelin is considered one of the most potent orexigenic peptide hormones and one that
promotes homeostatic and hedonic food intake. Research on ghrelin, however, has been …

Behavioral models are central to behavioral neuroscience. To study the neural mechanisms
of maladaptive behaviors (including binge eating and drug addiction), it is essential to …

Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin
opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence …