The vertebrate retina first evolved some 500 million years ago in ancestral marine
chordates. Since then, the eyes of different species have been tuned to best support their …

Trial-to-trial variability in the execution of movements and motor skills is ubiquitous and
widely considered to be the unwanted consequence of a noisy nervous system. However …

Neuroscience research has exploded, with more than fifty thousand neuroscientists applying
increasingly advanced methods. A mountain of new facts and mechanisms has emerged …

Noise—random disturbances of signals—poses a fundamental problem for information
processing and affects all aspects of nervous-system function. However, the nature, amount …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Darwinian evolution tends to produce energy-efficient outcomes. On the other hand, energy
limits computation, be it neural and probabilistic or digital and logical. Taking a particular …

1416-Pos Modulation of Human Stem Cell Derived Neuron Activity through Addition of an
External Conductance using Dynamic Clamp Brian K. Panama1, Leigh Korbel1, Brandon …

CNS axons differ in diameter (d) by nearly 100-fold (∼ 0.1–10 μm); therefore, they differ in
cross-sectional area (d 2) and volume by nearly 10,000-fold. If, as found for optic nerve …

Introduction Studies of categorical decision-making attempt to understand behavior by
probing how different features of complex and changing environments guide the selection of …

Action potentials in nonmyelinated axons are considered to contribute substantially to
activity-dependent brain metabolism. Here we show that fast Na+ current decay and delayed …