Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …

Abstract Cancer-associated fibroblasts (CAFs), enriched in the tumor stroma, have received
increasing attention because of their multifaceted effects on tumorigenesis, development …

Tumours are composed of tumour cells and the surrounding tumour microenvironment
(TME), and the molecular characterisation of the various elements of the TME and their …

Background Immunotherapy brings new hope to patients with advanced gastric cancer.
However, liver metastases can reduce the efficacy of immunotherapy in patients. Tumor …

Cancer-associated fibroblasts (CAFs) exhibit remarkable phenotypic heterogeneity, with
specific subsets implicated in immunosuppression in various malignancies. However …

Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the
second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific …

Cell pyroptosis, a Gasdermin-dependent programmed cell death characterized by
inflammasome, plays a complex and dynamic role in Gastric cancer (GC), a serious threat to …

Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and
growth regulation. They are key regulators of important cellular pathways in the tumor …

Gastric cancer (GC) is the fifth most common cancer worldwide, particularly prevalent in
Asia, especially in China, where both its incidence and mortality rates are significantly high …

High levels of M2 macrophage infiltration invariably contribute to poor cancer prognosis and
can be manipulated by metabolic reprogramming in the tumor microenvironment. However …