[HTML][HTML] Diagnosis of pulmonary hypertension

A Frost, D Badesch, JSR Gibbs… - European …, 2019 - publications.ersnet.org
A revised diagnostic algorithm provides guidelines for the diagnosis of patients with
suspected pulmonary hypertension, both prior to and following referral to expert centres, and …

Molecular genetic framework underlying pulmonary arterial hypertension

L Southgate, RD Machado, S Gräf… - Nature Reviews …, 2020 - nature.com
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder typified by occlusion
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …

Clinical trial design and new therapies for pulmonary arterial hypertension

O Sitbon, M Gomberg-Maitland… - European …, 2019 - publications.ersnet.org
Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on
case reports and small series, and was largely ineffectual. As a deeper understanding of the …

Discovery of distinct immune phenotypes using machine learning in pulmonary arterial hypertension

AJ Sweatt, HK Hedlin, V Balasubramanian… - Circulation …, 2019 - ahajournals.org
Rationale: Accumulating evidence implicates inflammation in pulmonary arterial
hypertension (PAH) and therapies targeting immunity are under investigation, although it …

Characterisation of pediatric pulmonary hypertensive vascular disease from the PPHNet Registry

SH Abman, MP Mullen, LA Sleeper… - European …, 2021 - publications.ersnet.org
Background There are limited data about the range of diseases, natural history, age-
appropriate endpoints and optimal care for children with pulmonary hypertension (PH) …

Clinical characteristics and transplant-free survival across the spectrum of pulmonary vascular disease

AR Hemnes, JA Leopold, MK Radeva, GJ Beck… - Journal of the American …, 2022 - jacc.org
Abstract Background PVDOMICS (Pulmonary Vascular Disease Phenomics) is a precision
medicine initiative to characterize pulmonary vascular disease (PVD) using deep …

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the …

P Ameri, V Mercurio, P Pollesello… - European Journal of …, 2024 - Wiley Online Library
Pulmonary hypertension (PH) associated with left heart failure (LHF)(PH‐LHF) is one of the
most common causes of PH. It directly contributes to symptoms and reduced functional …

Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market

G Kafili, H Niknejad, E Tamjid, A Simchi - Frontiers in Bioengineering …, 2024 - frontiersin.org
In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue
regeneration and has been of immense interest for clinical applications. AM is an abundant …

[HTML][HTML] Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension

H Daniell, V Mangu, B Yakubov, J Park, P Habibi, Y Shi… - Biomaterials, 2020 - Elsevier
Pulmonary arterial hypertension (PAH) is a deadly and uncurable disease characterized by
remodeling of the pulmonary vasculature and increased pulmonary artery pressure …

Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension

K Hirsch, S Nolley, DD Ralph, Y Zheng… - The Journal of Heart and …, 2023 - Elsevier
Background Subtypes of pulmonary arterial hypertension (PAH) differ in both fundamental
disease features and clinical outcomes. Angiogenesis and inflammation represent disease …