The landscape of mRNA nanomedicine

X Huang, N Kong, X Zhang, Y Cao, R Langer, W Tao - Nature Medicine, 2022 - nature.com
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

mRNA-based cancer therapeutics

C Liu, Q Shi, X Huang, S Koo, N Kong, W Tao - Nature Reviews Cancer, 2023 - nature.com
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Drugging p53 in cancer: one protein, many targets

O Hassin, M Oren - Nature Reviews Drug Discovery, 2023 - nature.com
Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

J Ouyang, A **e, J Zhou, R Liu, L Wang, H Liu… - Chemical Society …, 2022 - pubs.rsc.org
Traditional treatments such as chemotherapy and surgery usually cause severe side effects
and excruciating pain. The emergence of nanomedicines and minimally invasive therapies …

Nanotechnology-based mRNA vaccines

S Chen, X Huang, Y Xue, E Álvarez-Benedicto… - Nature Reviews …, 2023 - nature.com
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

An ionizable lipid toolbox for RNA delivery

X Han, H Zhang, K Butowska, KL Swingle… - Nature …, 2021 - nature.com
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited
significantly from decades of research on lipid nanoparticles, specifically its key component …

Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

[HTML][HTML] Lipid nanoparticles for mRNA delivery

X Hou, T Zaks, R Langer, Y Dong - Nature Reviews Materials, 2021 - nature.com
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …