Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Direct difunctionalization of simple alkenes, the incorporation of two functional groups onto a
carbon–carbon double bond, is of particular interest to the chemical community owing to its …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Anthraquinones and their derivatives constitute a large group of quinoid compounds with
about 700 molecules described. They are widespread in fungi and their chemical diversity …

Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …

Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …

Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of
natural product with a broad range of biological activities. Polyketide synthases (PKSs) …

Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …

Antibiotics revolutionized medicine and remain its cornerstone. Despite their global
importance and the continuous threat of resistant pathogens, few antibiotics have been …

Pericyclases are an emerging family of enzymes catalyzing pericyclic reactions. A class of
lipocalin-like enzymes recently characterized as Diels–Alderases (DAses) catalyze decalin …