[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy

KB Bader, E Vlaisavljevich, AD Maxwell - Ultrasound in medicine & biology, 2019 - Elsevier
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

The histotripsy spectrum: differences and similarities in techniques and instrumentation

RP Williams, JC Simon, VA Khokhlova… - International Journal …, 2023 - Taylor & Francis
Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …

Modeling tissue-selective cavitation damage

L Mancia, E Vlaisavljevich, N Yousefi… - Physics in Medicine …, 2019 - iopscience.iop.org
The destructive growth and collapse of cavitation bubbles are used for therapeutic purposes
in focused ultrasound procedures and can contribute to tissue damage in traumatic injuries …

[HTML][HTML] Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: Molecular insights and therapeutic prospects

Z Bi, Y Cai, X Shi, J Chen, D Li, P Zhang… - Chemical Engineering …, 2024 - Elsevier
The skeletal system is essential for preserving body structure and facilitating mobility;
however, bone diseases frequently result in significant disabilities, necessitating the …

[HTML][HTML] Mechanisms of nuclei growth in ultrasound bubble nucleation

MO de Andrade, R Haqshenas, KJ Pahk… - Ultrasonics …, 2022 - Elsevier
This paper interrogates the intersections between bubble dynamics and classical nucleation
theory (CNT) towards constructing a model that describes intermediary nucleation events …

Predicting tissue susceptibility to mechanical cavitation damage in therapeutic ultrasound

L Mancia, E Vlaisavljevich, Z Xu, E Johnsen - Ultrasound in medicine & …, 2017 - Elsevier
Histotripsy is a develo** focused ultrasound procedure that uses cavitation bubbles to
mechanically homogenize soft tissue. To better understand the mechanics of tissue damage …

Single–bubble dynamics in histotripsy and high–amplitude ultrasound: Modeling and validation

L Mancia, M Rodriguez, J Sukovich, Z Xu… - Physics in Medicine & …, 2020 - iopscience.iop.org
A variety of approaches have been used to model the dynamics of a single, isolated bubble
nucleated by a microsecond length high–amplitude ultrasound pulse (eg a histotripsy …

Comparative study of the dynamics of laser and acoustically generated bubbles in viscoelastic media

CT Wilson, TL Hall, E Johnsen, L Mancia, M Rodriguez… - Physical Review E, 2019 - APS
Experimental observations of the growth and collapse of acoustically and laser-nucleated
single bubbles in water and agarose gels of varying stiffness are presented. The maximum …

Acoustic cavitation rheometry

L Mancia, J Yang, JS Spratt, JR Sukovich, Z Xu… - Soft Matter, 2021 - pubs.rsc.org
Characterization of soft materials is challenging due to their high compliance and the strain-
rate dependence of their mechanical properties. The inertial microcavitation-based high …