Therapeutic targeting of tumour myeloid cells
ST Barry, DI Gabrilovich, OJ Sansom… - Nature Reviews …, 2023 - nature.com
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
Clinical and translational advances in ovarian cancer therapy
Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …
is initially very responsive to platinum-based chemotherapy. However, the majority of …
A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses
X Wang, Y Liu, C Xue, Y Hu, Y Zhao, K Cai, M Li… - Nature …, 2022 - nature.com
Abstract cGAS-STING pathway is a key DNA-sensing machinery and emerges as a
promising target to overcome the immunoresistance of solid tumors. Here we describe a …
promising target to overcome the immunoresistance of solid tumors. Here we describe a …
The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
Immunogenic PANoptosis‐Initiated Cancer Sono‐Immune Reediting Nanotherapy by Iteratively Boosting Cancer Immunity Cycle
L Zhou, J Lyu, F Liu, Y Su, L Feng… - Advanced …, 2024 - Wiley Online Library
The cancer‐immune cycle conceptualized the mechanisms of driving T cell responses to
tumors, but w as limited by immunological ignorance elicited by tumor inherent …
tumors, but w as limited by immunological ignorance elicited by tumor inherent …
The complexity of immune evasion mechanisms throughout the metastatic cascade
NM Haynes, TB Chadwick, BS Parker - Nature Immunology, 2024 - nature.com
Metastasis, the spread of cancer from a primary site to distant organs, is an important
challenge in oncology. This Review explores the complexities of immune escape …
challenge in oncology. This Review explores the complexities of immune escape …
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
Macrophages play a pivotal role in tumor immunity. We report that reprogramming of
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …
The DNA damage response and inflammation in cancer
Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
Nimbolide targets RNF114 to induce the trap** of PARP1 and synthetic lethality in BRCA-mutated cancer
Recent studies have pointed to PARP1 trap** as a key determinant of the anticancer
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …