Osteoimmunology: the conceptual framework unifying the immune and skeletal systems

K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017‏ - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Semaphorins and their signaling mechanisms

LT Alto, JR Terman - Semaphorin Signaling: Methods and Protocols, 2017‏ - Springer
Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

IC Clark, C Gutiérrez-Vázquez, MA Wheeler, Z Li… - Science, 2021‏ - science.org
INTRODUCTION Glial cells of the central nervous system (CNS), including astrocytes and
microglia, play critical roles in development, tissue repair, and homeostasis. However …

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

X Zhou, S Wahane, MS Friedl, M Kluge… - Nature …, 2020‏ - nature.com
Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to
form a protective barrier that seals the wound and facilitates debris clearing, inflammatory …

Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease

Y Huang, M Wang, H Ni, J Zhang, A Li, B Hu… - Nature …, 2024‏ - nature.com
Communication between glial cells has a profound impact on the pathophysiology of
Alzheimer's disease (AD). We reveal here that reactive astrocytes control cell distancing in …

Role of the immune system in the development of the central nervous system

K Morimoto, K Nakajima - Frontiers in Neuroscience, 2019‏ - frontiersin.org
The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …

Osteoprotection by semaphorin 3A

M Hayashi, T Nakashima, M Taniguchi, T Kodama… - Nature, 2012‏ - nature.com
The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and
bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone …

Whole-genome resequencing reveals loci under selection during chicken domestication

CJ Rubin, MC Zody, J Eriksson, JRS Meadows… - Nature, 2010‏ - nature.com
Domestic animals are excellent models for genetic studies of phenotypic evolution,,. They
have evolved genetic adaptations to a new environment, the farm, and have been subjected …

Mechanisms and molecules of neuronal wiring: a primer

AL Kolodkin, M Tessier-Lavigne - Cold Spring Harbor …, 2011‏ - cshperspectives.cshlp.org
The complex patterns of neuronal wiring in the adult nervous system depend on a series of
guidance events during neural development that establish a framework on which functional …

Semaphorins in adult nervous system plasticity and disease

D Carulli, F De Winter, J Verhaagen - Frontiers in synaptic …, 2021‏ - frontiersin.org
Semaphorins, originally discovered as guidance cues for develo** axons, are involved in
many processes that shape the nervous system during development, from neuronal …