Parkinson's disease

LV Kalia, AE Lang - The Lancet, 2015 - thelancet.com
Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been characterised by the classical motor features of parkinsonism associated with Lewy …

Clinical neurology and epidemiology of the major neurodegenerative diseases

MG Erkkinen, MO Kim… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Neuromodulation in epilepsy: state-of-the-art approved therapies

P Ryvlin, S Rheims, LJ Hirsch, A Sokolov… - The Lancet …, 2021 - thelancet.com
Three neuromodulation therapies have been appropriately tested and approved in refractory
focal epilepsies: vagus nerve stimulation (VNS), deep brain stimulation of the anterior …

[HTML][HTML] Parkinson's disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis

G DeMaagd, A Philip - Pharmacy and therapeutics, 2015 - ncbi.nlm.nih.gov
Parkinson’s Disease and Its Management - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search …

Gastrointestinal dysfunction in Parkinson's disease

A Fasano, NP Visanji, LWC Liu, AE Lang… - The Lancet …, 2015 - thelancet.com
Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's
disease has increased substantially in the past decade. The entire gastrointestinal tract is …

Direct and indirect pathways of basal ganglia: a critical reappraisal

P Calabresi, B Picconi, A Tozzi, V Ghiglieri… - Nature …, 2014 - nature.com
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …

Distinct symptom-specific treatment targets for circuit-based neuromodulation

SH Siddiqi, SF Taylor, D Cooke… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: Treatment of different depression symptoms may require different brain
stimulation targets with different underlying brain circuits. The authors sought to identify such …

Corticostriatal connectivity and its role in disease

GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Levodopa‐induced dyskinesia in Parkinson disease: current and evolving concepts

AJ Espay, F Morgante, A Merola, A Fasano… - Annals of …, 2018 - Wiley Online Library
Levodopa‐induced dyskinesia is a common complication in Parkinson disease. Pathogenic
mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa …

Rhythm and music-based interventions in motor rehabilitation: current evidence and future perspectives

T Braun Janzen, Y Koshimori, NM Richard… - Frontiers in human …, 2022 - frontiersin.org
Research in basic and clinical neuroscience of music conducted over the past decades has
begun to uncover music's high potential as a tool for rehabilitation. Advances in our …