[HTML][HTML] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Autophagy in healthy aging and disease
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
Ageing-associated changes in transcriptional elongation influence longevity
C Debès, A Papadakis, S Grönke, Ö Karalay, LS Tain… - Nature, 2023 - nature.com
Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key
challenge is to avoid adverse side effects from continuous dosing. Here we show that …
challenge is to avoid adverse side effects from continuous dosing. Here we show that …
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
Development is tightly connected to aging, but whether pharmacologically targeting
development can extend life remains unknown. Here, we subjected genetically diverse …
development can extend life remains unknown. Here, we subjected genetically diverse …
Genomic instability and epigenetic changes during aging
Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …
mortality rate. This scientific review focuses on the central importance of genomic instability …
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
O Motiño, F Lambertucci… - Proceedings of the …, 2022 - National Acad Sciences
Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor
(DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a …
(DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a …
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin
Pharmacological attenuation of mTOR presents a promising route for delay of age-related
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …
Evaluation of off-label rapamycin use to promote healthspan in 333 adults
TL Kaeberlein, AS Green, G Haddad, J Hudson… - GeroScience, 2023 - Springer
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-
inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and …
inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and …
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system
Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in
diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are …
diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are …