In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

Angiogenesis assays based on in vitro capillary-like growth of endothelial cells (EC) are
widely used, either to evaluate the effect of anti-and pro-angiogenesis drugs of interest, or to …

Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive tumors all over the
world, has a generally poor prognosis, and its progression is positively correlated with the …

Although antiangiogenic therapy has been used in gastric cancer, disease progression due
to drug resistance remains common. Neutrophils play an important role in the occurrence …

Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …