The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
Antibacterial drug discovery in the resistance era
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …
researchers, policymakers, politicians and the public at large. The evolution and widespread …
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability
INTRODUCTION Temperature is crucially important to life. Small temperature changes can
differentiate optimal and lethal growth conditions of living organisms. Because of the higher …
differentiate optimal and lethal growth conditions of living organisms. Because of the higher …
Soil pH correlates with the co-occurrence and assemblage process of diazotrophic communities in rhizosphere and bulk soils of wheat fields
Biological nitrogen fixation contributes to the pool of plant-available N in both bulk soil and
the rhizosphere. Here we investigated the co-association and assemblage process of …
the rhizosphere. Here we investigated the co-association and assemblage process of …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
AF2Complex predicts direct physical interactions in multimeric proteins with deep learning
Accurate descriptions of protein-protein interactions are essential for understanding
biological systems. Remarkably accurate atomic structures have been recently computed for …
biological systems. Remarkably accurate atomic structures have been recently computed for …
Protein interactions in human pathogens revealed through deep learning
Identification of bacterial protein–protein interactions and predicting the structures of these
complexes could aid in the understanding of pathogenicity mechanisms and develo** …
complexes could aid in the understanding of pathogenicity mechanisms and develo** …
Small RNAs in bacteria and archaea: who they are, what they do, and how they do it
EGH Wagner, P Romby - Advances in genetics, 2015 - Elsevier
Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …
ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions
TS Furey - Nature Reviews Genetics, 2012 - nature.com
Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …