Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks

H Kim, G Hu, AJ Graham, GX Gu… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Abstract Three-dimensional (3D) printing can be beneficial to tissue engineers and the
regenerative medicine community because of its potential to rapidly build elaborate 3D …

Topology of three-dimensional active nematic turbulence confined to droplets

S Čopar, J Aplinc, Ž Kos, S Žumer, M Ravnik - Physical Review X, 2019 - APS
Active nematics contain topological defects that (under sufficient activity) move, create, and
annihilate in a chaotic quasi-steady state, called active turbulence. However, understanding …

Liquid-crystal organization of liver tissue

H Morales-Navarrete, H Nonaka, A Scholich… - Elife, 2019 - elifesciences.org
Functional tissue architecture originates by self-assembly of distinct cell types, following
tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was …

Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

L Belicova, U Repnik, J Delpierre, E Gralinska… - Journal of Cell …, 2021 - rupress.org
Lumen morphogenesis results from the interplay between molecular pathways and
mechanical forces. In several organs, epithelial cells share their apical surfaces to form a …

Learning developmental mode dynamics from single-cell trajectories

N Romeo, A Hastewell, A Mietke, J Dunkel - Elife, 2021 - elifesciences.org
Embryogenesis is a multiscale process during which developmental symmetry breaking
transitions give rise to complex multicellular organisms. Recent advances in high-resolution …

Resilience of three-dimensional sinusoidal networks in liver tissue

J Karschau, A Scholich, J Wise… - PLoS computational …, 2020 - journals.plos.org
Can three-dimensional, microvasculature networks still ensure blood supply if individual
links fail? We address this question in the sinusoidal network, a plexus-like microvasculature …

Induction of bile canaliculi-forming hepatocytes from human pluripotent stem cells

L Matakovic, AW Overeem, K Klappe… - … : Methods and Protocols, 2022 - Springer
Cell polarity and formation of bile canaliculi can be achieved in hepatocytes which are
generated from patient-derived induced pluripotent stem cells. This allows for the study of …

Curvature strains as a global orchestrator of morphogenesis

JB Kirkegaard - Physical Review Research, 2022 - APS
Successful morphogenesis on the scale of organs or organisms requires strict coordination
between the constituent cells whose action on the local scale must be orchestrated …

Geometric control of active flows

J Neipel - 2024 - pure.mpg.de
The development of an organism starting from a fertilized egg involves the self-organized
formation of patterns and the generation of shape. Patterns and shapes are characterized by …

Geometry and Transport in Development

NF Romeo - 2023 - search.proquest.com
Shape changes are some of the most visually striking features of biological development at
all scales of living matter. With recent advances in high-resolution microscopy, it becomes …