Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

The rapid expansion of the elderly population has led to the recent epidemic of age-related
diseases, including increased incidence and mortality of chronic and acute lung diseases …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

This review summarizes the interaction between the regulatory system of respiration and
cerebral vasculature. Some clinical reports provide evidence for the association between …

Introduction: Cognitive impairment (CI) is an important but an under-recognized extra-
pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the …

Background/Aim: Evidence exists that oxidative stress and oxidative damage play a pivotal
role in chronic obstructive pulmonary disease (COPD). Oligomeric proanthocyanidins …

This study examined cerebral blood flow (CBF) and its regulation before and after a short-
term periodized aerobic exercise training intervention in patients with chronic obstructive …

Objective Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide–cyclic
guanosine 3′, 5′-monophosphate (NO–cGMP) signaling pathway, and its …

Cerebral oxygen extraction fraction is an important physiological index of the brain's oxygen
consumption and supply and has been suggested to be a potential biomarker for a number …

The brain is a vital organ that relies on a constant and adequate blood flow to match oxygen
and glucose delivery with the local metabolic demands of active neurons. Thus exquisite …