Role of the CXCL13/CXCR5 axis in autoimmune diseases

Z Pan, T Zhu, Y Liu, N Zhang - Frontiers in Immunology, 2022 - frontiersin.org
CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment

X Wang, D Fan, X Cao, Q Ye, Q Wang, M Zhang… - Antioxidants, 2022 - mdpi.com
Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to
modified self-antigens and immune system abnormalities, eventually leading to synovitis …

[HTML][HTML] CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer

B Wang, M Wang, D Ao, X Wei - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Chemokine CXC motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays
an important role in the immune system. The interaction between CXCL13 and its receptor …

Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

MA Murayama, J Shimizu, C Miyabe, K Yudo… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis

MJ López-Armada, JA Fernández-Rodríguez… - Antioxidants, 2022 - mdpi.com
Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

Role of chemokine systems in cancer and inflammatory diseases

H Li, M Wu, X Zhao - MedComm, 2022 - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Conditioned medium–is it an undervalued lab waste with the potential for osteoarthritis management?

MA Rosochowicz, MS Lach, M Richter… - Stem Cell Reviews and …, 2023 - Springer
Background The approaches currently used in osteoarthritis (OA) are mainly short-term
solutions with unsatisfactory outcomes. Cell-based therapies are still controversial (in terms …

CXCL13 in cancer and other diseases: biological functions, clinical significance, and therapeutic opportunities

SH Gao, SZ Liu, GZ Wang, GB Zhou - Life, 2021 - mdpi.com
The development of cancer is a multistep and complex process involving interactions
between tumor cells and the tumor microenvironment (TME). CXC chemokine ligand 13 …

G-Protein-Coupled receptors in rheumatoid arthritis: Recent insights into mechanisms and functional roles

J Zhao, K Wei, P Jiang, C Chang, L Xu, L Xu… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

The role of CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 ligands in molecular cancer processes and clinical aspects of acute myeloid leukemia (AML)

J Korbecki, P Kupnicka, K Barczak, M Bosiacki… - Cancers, 2023 - mdpi.com
Simple Summary AML is a type of leukemia with a very unfavorable prognosis. Some of the
new therapeutic targets that are being investigated by researchers worldwide are …