Initial expectations for genome-wide association studies were high, as such studies
promised to rapidly transform personalized medicine with individualized disease risk …

Non-alcoholic fatty liver disease (NAFLD) is projected to become the leading cause of
hepatocellular carcinoma (HCC) in many countries. Many risk factors for NAFLD are also …

Motivation Polygenic scores have become a central tool in human genetics research.
LDpred is a popular method for deriving polygenic scores based on summary statistics and …

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …

Apart from high-risk scenarios such as the presence of highly penetrant genetic mutations,
breast screening typically comprises mammography or tomosynthesis strategies defined by …

Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Importance The age-based or “one-size-fits-all” breast screening approach does not take
into account the individual variation in risk. Mammography screening reduces death from …

Background It is proposed that, through restriction to individuals delineated as high risk,
polygenic risk scores (PRSs) might enable more efficient targeting of existing cancer …

Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and
environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A …

Objectives To develop and validate a genetic tool to predict age of onset of aggressive
prostate cancer (PCa) and to guide decisions of who to screen and at what age. Design …