In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a
protein is determined by its amino acid sequence. This work laid the foundation for the …

Alternative splicing is commonly believed to be a major source of cellular protein diversity.
However, although many thousands of alternatively spliced transcripts are routinely detected …

Single-nuclei RNA sequencing characterizes cell types at the gene level. However,
compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack …

Most human genes generate multiple transcript isoforms. The differential expression of these
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …

Tress and colleagues proposed that only a minor fraction of splice variants detected in
transcriptome profiling data are translated and, therefore, that most splice variants have little …

The role of alternative splicing is one of the great unanswered questions in cellular biology.
There is strong evidence for alternative splicing at the transcript level, and transcriptomics …

Alternative splicing (AS) generates multiple transcripts from the same gene, however, AS
contribution to proteome complexity remains elusive in plants. AS is prevalent under stress …

High-throughput RNA sequencing (RNA-seq) has revealed an enormous complexity of
alternative splicing (AS) across diverse cell and tissue types. However, it is currently …

Abstract APPRIS (https://appris. bioinfo. cnio. es) is a well-established database housing
annotations for protein isoforms for a range of species. APPRIS selects principal isoforms …