Carbapenem resistance in gram-negative bacteria has caused a global epidemic that
continues to grow. Although carbapenemase-producing Enterobacteriaceae have received …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

Although hypervirulent Klebsiella pneumoniae (hvKP) can produce community-acquired
infections that are fatal in young and adult hosts, such as pyogenic liver abscess …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Plasmid persistence in bacterial populations is strongly influenced by the fitness effects
associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial …

Along with the recent spread of multidrug-resistant bacteria, outbreaks of extended-spectrum
β-lactamase (ESBL) and carbapenemase-producing bacteria present a serious challenge to …

During 2020–2021, countries in Latin America and the Caribbean reported clinical
emergence of carbapenemase-producing Enterobacterales that had not been previously …

Abstract Background Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for
the treatment of complicated intra-abdominal and urinary tract infections, as well as hospital …

Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …