Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

This review provides an overview of metal-based anticancer drugs and drug candidates. In
particular, we focus on metal complexes that can be activated in the reducing environment of …

Metallic radionuclides possess a variety of half-lives, emission types, energies, and
branching ratios, making it possible to apply them as diagnostic and/or therapeutic agents …

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host
macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation …

The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …

Systemic cytotoxic (anti-proliferative) anticancer drugs rely primarily for their therapeutic
effect on cytokinetic differences between cancer and normal cells. One approach aimed at …

Tumour hypoxia represents a significant challenge to the curability of human tumours
leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be …

Molecular imaging is an important scientific discipline that plays a major role in clinical
medicine and pharmaceutical development. While several imaging modalities including X …

Copper (II) bis (thiosemicarbazone) complexes labelled with Cu-60/62/64 are useful
radiopharmaceuticals for imaging blood flow and hypoxic tissues in vivo. The aim of this …

This review gives an account of the coordination chemistry of thiosemicarbazone ligands
with three (tridentate) or four (tetradentate) potential donor atoms. The syntheses and …