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Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Advances in targeting cyclic nucleotide phosphodiesterases
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …
Rational multitargeted drug design strategy from the perspective of a medicinal chemist
X Li, X Li, F Liu, S Li, D Shi - Journal of Medicinal Chemistry, 2021 - ACS Publications
The development of multitarget-directed ligands (MTDLs) has become a widely focused
research topic, but rational design remains as an enormous challenge. This paper reviews …
research topic, but rational design remains as an enormous challenge. This paper reviews …
Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions
SH Francis, MA Blount, JD Corbin - Physiological reviews, 2011 - journals.physiology.org
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
[HTML][HTML] Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors
Abstract Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
M Conti, J Beavo - Annu. Rev. Biochem., 2007 - annualreviews.org
Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …
Intramolecular hydrogen bonding in medicinal chemistry
The formation of intramolecular hydrogen bonds has a very pronounced effect on molecular
structure and properties. We study both aspects in detail with the aim of enabling a more …
structure and properties. We study both aspects in detail with the aim of enabling a more …
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders
Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …
Keynote review: phosphodiesterase-4 as a therapeutic target
MD Houslay, P Schafer, KYJ Zhang - Drug discovery today, 2005 - Elsevier
Cyclic AMP (cAMP) is a key second messenger in all cells. It is compartmentalized within
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …
Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
DA Ryjenkov, M Tarutina, OV Moskvin… - Journal of …, 2005 - Am Soc Microbiol
Proteins containing GGDEF domains are encoded in the majority of sequenced bacterial
genomes. In several species, these proteins have been implicated in biosynthesis of …
genomes. In several species, these proteins have been implicated in biosynthesis of …