IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
Inducible antibacterial responses in macrophages
Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
Stowaways in the cargo: Contaminating nucleic acids in rAAV preparations for gene therapy.
Recombinant AAV (rAAV) is the most used delivery vector for clinical gene therapy.
However, many issues must be addressed before safer and more widespread …
However, many issues must be addressed before safer and more widespread …
Regulation of human interferon signaling by transposon exonization
Innate immune signaling is essential for clearing pathogens and damaged cells and must be
tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the …
tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the …
Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system
Devising new and more efficient protocols to analyze the phenotypes of non-human
primates, as well as their complex nervous systems, is rapidly becoming of paramount …
primates, as well as their complex nervous systems, is rapidly becoming of paramount …
The evolution of powerful yet perilous immune systems
The mammalian immune system packs serious punch against infection but can also cause
harm: for example, coronavirus disease 2019 (COVID-19) made headline news of the …
harm: for example, coronavirus disease 2019 (COVID-19) made headline news of the …
Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy
MR Emami, A Espinoza, CS Young, F Ma… - … Therapy-Methods & …, 2023 - cell.com
High systemic doses of adeno-associated viruses (AAVs) have been associated with
immune-related serious adverse events (SAEs). Although AAV was well tolerated in …
immune-related serious adverse events (SAEs). Although AAV was well tolerated in …
Deciphering the interdependent labyrinth between gut microbiota and the immune system
The human gut microbiome interacts with each other and the host, which has significant
effects on health and disease development. Intestinal homeostasis and inflammation are …
effects on health and disease development. Intestinal homeostasis and inflammation are …
Contemporary small-scale subsistence populations offer unique insights into human musculoskeletal health and aging
J Stieglitz - Science Advances, 2024 - science.org
Human foragers avoid noncommunicable diseases that are leading causes of mortality,
partly because physically active lifestyles promote healthy aging. High activity levels also …
partly because physically active lifestyles promote healthy aging. High activity levels also …