The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

DNA-damaging therapies represent the most frequently used non-surgical anticancer
strategies in the treatment of human tumors. These therapies can kill tumor cells, but at the …

The ability of cells to detect and repair DNA double-strand breaks (DSBs) within the complex
architecture of the genome requires co-ordination between the DNA repair machinery and …

Higher order chromatin structure has an impact on all nuclear functions, including the DNA
damage response. Over the past several years, it has become increasingly clear that …

DNA repair must take place in the context of chromatin, and chromatin modifications and
DNA repair are intimately linked. The study of double-strand break repair has revealed …

A sequence variant of histone H2A called H2AX is one of the key components of chromatin
involved in DNA damage response induced by different genotoxic stresses. Phosphorylated …

Histone acetylation is required for many aspects of gene regulation, genome maintenance
and metabolism and dysfunctional acetylation is implicated in numerous diseases, including …

ATM is the most significant molecule involved in monitoring the genomic integrity of the cell.
Any damage done to DNA relentlessly challenges the cellular machinery involved in …

A DNA double strand break (DSB) is a highly toxic lesion, which can generate genetic
instability and profound genome rearrangements. However, DSBs are required to generate …

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …