Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-
1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid
haematopoiesis that form an essential interface between the innate sensing of pathogens …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, sha** adaptive and innate immunity. Over the years, a …

Genetic screens help infer gene function in mammalian cells, but it has remained difficult to
assay complex phenotypes—such as transcriptional profiles—at scale. Here, we develop …

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver …

Inflammation and tissue damage associated with pancreatitis can precede or occur
concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC …

It is well understood that antigen-presenting cells (APCs) within tumors typically do not
maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse …