Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions
Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
Small-cell lung cancer: what we know, what we need to know and the path forward
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …
cancers and is pathologically, molecularly, biologically and clinically very different from other …
Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
MYC deregulation in primary human cancers
MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …
its numerous target genes. As such, MYC is a master regulator of many processes, including …
[HTML][HTML] Genomic and transcriptomic characterization of natural killer T cell lymphoma
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-
Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify …
Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify …
The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis
PA Carroll, BW Freie, H Mathsyaraja… - Frontiers of medicine, 2018 - Springer
Transcription factor networks have evolved in order to control, coordinate, and separate, the
functions of distinct network modules spatially and temporally. In this review we focus on the …
functions of distinct network modules spatially and temporally. In this review we focus on the …
Marked for death: targeting epigenetic changes in cancer
SX Pfister, A Ashworth - Nature reviews Drug discovery, 2017 - nature.com
In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …
common in human cancers. Therapeutic strategies are now being developed to target …
PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling
B Yao, T Gui, X Zeng, Y Deng, Z Wang, Y Wang… - Genome medicine, 2021 - Springer
Background Aberrant changes in epigenetic mechanisms such as histone modifications play
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …
MYC dysregulation in the progression of multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy preceded by a premalignant stage,
named monoclonal gammopathy of undetermined significance (MGUS), and often a …
named monoclonal gammopathy of undetermined significance (MGUS), and often a …
Killing SCLC: insights into how to target a shapeshifting tumor
Small cell lung cancer (SCLC) is a rapidly growing, highly metastatic, and relatively immune-
cold lung cancer subtype. Historically viewed in the laboratory and clinic as a single …
cold lung cancer subtype. Historically viewed in the laboratory and clinic as a single …