Biosynthesis of the anticancer drug Taxol in Taxus (yew) species involves 19 steps from the
universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial …

Taxus species are well-known for paclitaxel, which exhibits antitumor activities and is used
for treating various cancers. Although most Taxus species are widespread in many areas …

Background Taxol is an efficient anticancer drug accumulated in Taxus species.
Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids …

The results presented in this paper describe for the first time the presence of an inducible
enzyme in the biosynthetic pathway leading to the anticancer drug paclitaxel. Methyl …

The effects of oligosaccharide from Fusarium oxysprum on secondary metabolisms in
suspension cultures of Taxus chinensis var. mairei were investigated by detecting the …

Conifers (order Coniferales) are the largest and most diverse group of living gymnosperms
comprising more than 600 species of 60-65 genera in seven families, including the …

Geranylgeranyl diphosphate (GGPP) synthase, an enzyme that regulates taxane
biosynthesis, was purified to homogeneity from cell cultures of Taxus baccata. The …

The application of immunoaffinity chromatography for the purification of Taxus plant and cell
extracts prior to the HPLC analysis is described. Polyclonal antibodies raised against 10 …

In the NCI-sponsored plant-screening program for natural antitumor substances, taxol
(paclitaxel) was first isolated from the stem bark of the Pacific yew, Taxus brevifolia Nutt …

Cell suspension cultures of stem-derived callus of Taxus wallichiana in MS-F culture media
were found to produce three C-14 oxygenated taxoids and one regular taxoid. The taxoids …