The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

LA Díaz, JP Arab, A Louvet, R Bataller… - Nature Reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …

Update on NAFLD genetics: from new variants to the clinic

E Trépo, L Valenti - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy

YX **an, JP Weng, F Xu - Chinese medical journal, 2021 - mednexus.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, placing an increasing burden on human health. NAFLD is a complex …

Alcohol-related liver disease: basic mechanisms and clinical perspectives

SY Liu, IT Tsai, YC Hsu - International journal of molecular sciences, 2021 - mdpi.com
Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive
alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis …

Genetics of MASLD: The State of Art Update.

S Sookoian, Y Rotman, L Valenti - Clinical Gastroenterology and …, 2024 - Elsevier
Recent advances in the genetics of metabolic dysfunction-associated steatotic liver disease
(MASLD) are gradually revealing the mechanisms underlying the heterogeneity of the …

Global prevalence, incidence, and outcomes of alcohol related liver diseases: a systematic review and meta-analysis

X Niu, L Zhu, Y Xu, M Zhang, Y Hao, L Ma, Y Li… - BMC Public Health, 2023 - Springer
Background Alcohol related liver disease (ARLD) is one of the major chronic liver diseases
worldwide. This review aimed to describe the global prevalence, incidence, and outcomes of …

Genome‐wide association study and meta‐analysis on alcohol‐associated liver cirrhosis identifies genetic risk factors

TH Schwantes‐An, R Darlay, P Mathurin… - …, 2021 - Wiley Online Library
Background and Aims Only a minority of heavy drinkers progress to alcohol‐associated
cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie …

Toward genetic prediction of nonalcoholic fatty liver disease trajectories: PNPLA3 and beyond

M Krawczyk, R Liebe, F Lammert - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is on the verge of becoming the leading cause of
liver disease. NAFLD develops at the interface between environmental factors and inherited …

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers

JB Whitfield, TH Schwantes-An, R Darlay, GP Aithal… - Journal of …, 2022 - Elsevier
Background & Aims Only a minority of excess alcohol drinkers develop cirrhosis. We
developed and evaluated risk stratification scores to identify those at highest risk. Methods …