Cytokines in cancer pathogenesis and cancer therapy
G Dranoff - Nature Reviews Cancer, 2004 - nature.com
The mixture of cytokines that is produced in the tumour microenvironment has an important
role in cancer pathogenesis. Cytokines that are released in response to infection …
role in cancer pathogenesis. Cytokines that are released in response to infection …
Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade
LA Emens - Expert review of anticancer therapy, 2012 - Taylor & Francis
Breast cancer is immunogenic, and infiltrating immune cells in primary breast tumors convey
important clinical prognostic and predictive information. Furthermore, the immune system is …
important clinical prognostic and predictive information. Furthermore, the immune system is …
[HTML][HTML] Systemic spread is an early step in breast cancer
Y Hüsemann, JB Geigl, F Schubert, P Musiani… - Cancer cell, 2008 - cell.com
It is widely accepted that metastasis is a late event in cancer progression. Here, however, we
show that tumor cells can disseminate systemically from earliest epithelial alterations in HER …
show that tumor cells can disseminate systemically from earliest epithelial alterations in HER …
Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and sha** tumor immunogenicity
Cellular transformation and tumor development result from an accumulation of mutational
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100 …
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100 …
Perforin-mediated target-cell death and immune homeostasis
The granule exocytosis pathway of cytotoxic lymphocytes is crucial for immune surveillance
and homeostasis. The trafficking of granule components, including the membrane-disruptive …
and homeostasis. The trafficking of granule components, including the membrane-disruptive …
Tumor antigen–targeted, monoclonal antibody–based immunotherapy: clinical response, cellular immunity, and immunoescape
Purpose Tumor antigen (TA)–targeted monoclonal antibodies (mAb), rituximab,
trastuzumab, and cetuximab, are clinically effective for some advanced malignancies …
trastuzumab, and cetuximab, are clinically effective for some advanced malignancies …
Vaccines for tumour prevention
Despite tremendous progress in basic and epidemiological research, effective prevention of
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer
NH Stoecklein, SB Hosch, M Bezler, F Stern… - Cancer cell, 2008 - cell.com
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic
decisions neglects evolutionary aspects of cancer progression. To address this problem, we …
decisions neglects evolutionary aspects of cancer progression. To address this problem, we …
Cancer Immunotherapy Based on Killing of Salmonella-Infected Tumor Cells
A major obstacle for the development of effective immunotherapy is the ability of tumors to
escape the immune system. The possibility to kill tumor cells because they are recognized …
escape the immune system. The possibility to kill tumor cells because they are recognized …
Apoptosis induced by the lymphocyte effector molecule perforin
Recent progress has been made in discovering structure/function relationships of the
cytotoxic lymphocyte pore-forming protein—perforin—and its role in immune regulation …
cytotoxic lymphocyte pore-forming protein—perforin—and its role in immune regulation …