Adult epilepsy
Epilepsy is a common medical condition that affects people of all ages, races, social classes,
and geographical regions. Diagnosis of epilepsy remains clinical, and ancillary …
and geographical regions. Diagnosis of epilepsy remains clinical, and ancillary …
Epilepsy surgery for children and adolescents: evidence-based but underused
JH Cross, C Reilly, EG Delicado, ML Smith… - The Lancet Child & …, 2022 - thelancet.com
Paediatric epilepsy surgery is an increasingly used evidence-based management option
with low risks for complications. Developments in neuroimaging techniques and other …
with low risks for complications. Developments in neuroimaging techniques and other …
The ILAE consensus classification of focal cortical dysplasia: an update proposed by an ad hoc task force of the ILAE diagnostic methods commission
Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous
research and consensus agreement to improve disease definition and classification. An …
research and consensus agreement to improve disease definition and classification. An …
Timing of referral to evaluate for epilepsy surgery: Expert Consensus Recommendations from the Surgical Therapies Commission of the International League Against …
Epilepsy surgery is the treatment of choice for patients with drug‐resistant seizures. A timely
evaluation for surgical candidacy can be life‐saving for patients who are identified as …
evaluation for surgical candidacy can be life‐saving for patients who are identified as …
Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind …
W Zweiphenning, MA van't Klooster… - The Lancet …, 2022 - thelancet.com
Background Intraoperative electrocorticography is used to tailor epilepsy surgery by
analysing interictal spikes or spike patterns that can delineate epileptogenic tissue. High …
analysing interictal spikes or spike patterns that can delineate epileptogenic tissue. High …
Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)
T Bonduelle, T Hartlieb, S Baldassari, NS Sim… - Acta neuropathologica …, 2021 - Springer
Focal malformations of cortical development (MCD) are linked to somatic brain mutations
occurring during neurodevelopment. Mild malformation of cortical development with …
occurring during neurodevelopment. Mild malformation of cortical development with …
Toward a better definition of focal cortical dysplasia: an iterative histopathological and genetic agreement trial
Objective Focal cortical dysplasia (FCD) is a major cause of difficult‐to‐treat epilepsy in
children and young adults, and the diagnosis is currently based on microscopic review of …
children and young adults, and the diagnosis is currently based on microscopic review of …
Contribution of somatic Ras/Raf/mitogen-activated protein kinase variants in the hippocampus in drug-resistant mesial temporal lobe epilepsy
Importance Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy
subtype and is often refractory to antiseizure medications. While most patients with MTLE do …
subtype and is often refractory to antiseizure medications. While most patients with MTLE do …
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions
Understanding the exact molecular mechanisms involved in the aetiology of epileptogenic
pathologies with or without tumour activity is essential for improving treatment of drug …
pathologies with or without tumour activity is essential for improving treatment of drug …
Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study
Objective Drug‐resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs).
The distribution of these lesions across the cerebral cortex and the impact of lesion location …
The distribution of these lesions across the cerebral cortex and the impact of lesion location …