Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …

The Eph family of receptor tyrosine kinases and their ephrin ligands are mediators of cell-
cell communication. Cleavage of ephrin-A2 by the ADAM10 membrane metalloprotease …

New blood vessels are initially formed through the assembly or sprouting of endothelial
cells, but the recruitment of supporting pericytes and vascular smooth muscle cells (mural …

Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use
of the affected limb and is associated with sprouting of new connections, a process that is …

Significant endeavor has been applied to identify functional therapeutic targets in
glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor …

Background: Eph receptors and their ligands, the ephrins, represent a large class of cell–cell
communication molecules with well-defined developmental functions. Their role in healthy …

Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and
adhesion of cells required to form and stabilize patterns of cell organization during …

The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

The Eph receptors comprise the largest group of receptor tyrosine kinases and are found in
a wide variety of cell types in develo** and mature tissues. Their ligands are the ephrins, a …