Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Extracellular vesicles from adipose tissue‐derived stem cells alleviate osteoporosis through osteoprotegerin and miR‐21‐5p

KS Lee, J Lee, HK Kim, SH Yeom… - Journal of …, 2021 - Wiley Online Library
Osteoporosis is one of the most common skeletal disorders caused by the imbalance
between bone formation and resorption, resulting in quantitative loss of bone tissue. Since …

[HTML][HTML] Isolation of extracellular vesicles with combined enrichment methods

J Stam, S Bartel, R Bischoff, JC Wolters - Journal of Chromatography B, 2021 - Elsevier
Extracellular vesicles (EVs) are currently of tremendous interest in many research
disciplines and EVs have potential for development of EV diagnostics or therapeutics. Most …

Principles and problems of exosome isolation from biological fluids

EI Yakubovich, AG Polischouk… - … ), Supplement Series A …, 2022 - Springer
Exosomes, the subclass of small membrane extracellular vesicles, have great diagnostic
and therapeutic potential, but the lack of standardized methods for their efficient isolation …

Stem cells and exosomes: new therapies for intervertebral disc degeneration

Z Krut, G Pelled, D Gazit, Z Gazit - Cells, 2021 - mdpi.com
Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic
and catabolic processes in the intervertebral disc, leading to an alteration in the composition …

Exosomes: Isolation, characterization, and biomedical applications

GN Alzhrani, ST Alanazi, SY Alsharif… - Cell Biology …, 2021 - Wiley Online Library
Exosomes are nano‐sized bioactive vesicles of 30–150 nm in diameter. They are secreted
by exocytosis of nearly all type of cells in to the extracellular fluid. Thereby, they can be …

Highlights on advancing frontiers in tissue engineering

N Ashammakhi, A GhavamiNejad, R Tutar… - … Engineering Part B …, 2022 - liebertpub.com
The field of tissue engineering continues to advance, sometimes in exponential leaps
forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a …