Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

The promising expectations about personalized medicine have opened the path to routine
large-scale sequencing and increased the importance of genetic counseling for hereditary …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

Tumours with specific DNA repair defects can be completely dependent on back-up DNA
repair pathways for their survival. This dependence can be exploited therapeutically to …

Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1
C61G mutation in the BRCA1 RING domain is a common pathogenic missense variant …

BRCA1, a well-known tumor suppressor with multiple interacting partners, is predicted to
have diverse biological functions. However, so far its only well-established role is in the …

Clinical mutation screening of the BRCA1 and BRCA2 genes for the presence of germline
inactivating mutations is used to identify individuals at elevated risk of breast and ovarian …

Mouse models of human cancer have played a vital role in understanding tumorigenesis
and answering experimental questions that other systems cannot address. Advances …