The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Liquid chromatography coupled to mass spectrometry (LC-MS) is one of the most powerful
tools in identifying and quantitating molecular species. Decreasing column diameter from …

Extracellular matrix (ECM) plays a multitude of roles, including supporting cells through
structural and biochemical interactions. ECM is damaged in the process of isolating human …

The extracellular matrix (ECM) is unique to each tissue and capable of guiding cell
differentiation, migration, morphology, and function. The ECM proteome of different …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The production of biomaterials that endow significant morphogenic and microenvironmental
cues for the constitution of cell integration and regeneration remains a key challenge in the …

Diabetes mellitus is a global disease requiring long-term treatment and monitoring. At
present, pancreas or islet transplantation is the only reliable treatment for achieving stable …

Islet transplantation (IT) offers the potential to restore euglycemia for patients with type 1
diabetes mellitus (T1DM). Despite improvements in islet isolation techniques and …

The extracellular matrix (ECM) provides an architectural meshwork that surrounds and
supports cells. The dysregulation of heavily post-translationally modified ECM proteins …

Tissue microenvironments are rich in signaling molecules. However, factors in the tissue
matrix that can serve as tissue-specific cues for engineering pancreatic tissues have not …