Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

OF Davies-Bolorunduro, O Osuolale, S Saibu… - Heliyon, 2021 - cell.com
Revived analysis interests in natural products in the hope of discovering new and novel
antileishmanial drug leads have been driven partially by the increasing incidence of drug …

The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery

S Lamotte, GF Späth, N Rachidi… - PLoS neglected tropical …, 2017 - journals.plos.org
The state of antileishmanial chemotherapy is strongly compromised by the emergence of
drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to …

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs

G Colotti, P Baiocco, A Fiorillo, A Boffi… - Future medicinal …, 2013 - Taylor & Francis
Leishmaniasis is a neglected disease that kills 60,000 people worldwide, and which is
caused by the protozoa Leishmania. The enzymes of the trypanothione pathway …

Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects

SA Ejazi, N Ali - Expert review of anti-infective therapy, 2013 - Taylor & Francis
Human visceral leishmaniasis (VL) continues to be a life-threatening neglected tropical
disease, with close to 200 million people at risk of infection globally. Epidemics and …

Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis

FB Magalhaes, AL Castro Neto, MB Nascimento… - PLoS …, 2017 - journals.plos.org
Current strategies for the control of zoonotic visceral leishmaniasis (VL) rely on its efficient
diagnosis in both human and canine hosts. The most promising and cost effective approach …

[HTML][HTML] Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB

Y Pérez-Pertejo, JM Escudero-Martínez… - International Journal for …, 2019 - Elsevier
Leishmania is the aethiological agent responsible for the visceral leishmaniasis, a serious
parasite-borne disease widely spread all over the World. The emergence of resistant strains …

Amino acid containing amphiphilic hydrogelators with antibacterial and antiparasitic activities

B Mondal, VK Gupta, B Hansda, A Bhoumik, T Mondal… - Soft Matter, 2022 - pubs.rsc.org
Nanoscale self-assembly of peptide constructs represents a promising means to present
bioactive motifs to develop new functional materials. Here, we present a series of peptide …

Development, Characterization, and In Vitro Biological Performance of Fluconazole‐Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis

MB Oliveira, G Calixto, M Graminha… - BioMed research …, 2015 - Wiley Online Library
Cutaneous leishmaniasis (CL) is a resistant form of leishmaniasis that is caused by a
parasite belonging to the genus Leishmania. FLU‐loaded microemulsions (MEs) were …

Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations

KH Baek, L Piel, T Rosazza, E Prina, GF Späth, JH No - Pathogens, 2020 - mdpi.com
Protozoan parasites of the genus Leishmania are the causative agents of leishmaniasis, a
spectrum of a disease that threatens public health worldwide. Although next-generation …