Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis
AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects
Revived analysis interests in natural products in the hope of discovering new and novel
antileishmanial drug leads have been driven partially by the increasing incidence of drug …
antileishmanial drug leads have been driven partially by the increasing incidence of drug …
The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery
S Lamotte, GF Späth, N Rachidi… - PLoS neglected tropical …, 2017 - journals.plos.org
The state of antileishmanial chemotherapy is strongly compromised by the emergence of
drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to …
drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to …
Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs
Leishmaniasis is a neglected disease that kills 60,000 people worldwide, and which is
caused by the protozoa Leishmania. The enzymes of the trypanothione pathway …
caused by the protozoa Leishmania. The enzymes of the trypanothione pathway …
Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects
Human visceral leishmaniasis (VL) continues to be a life-threatening neglected tropical
disease, with close to 200 million people at risk of infection globally. Epidemics and …
disease, with close to 200 million people at risk of infection globally. Epidemics and …
Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis
FB Magalhaes, AL Castro Neto, MB Nascimento… - PLoS …, 2017 - journals.plos.org
Current strategies for the control of zoonotic visceral leishmaniasis (VL) rely on its efficient
diagnosis in both human and canine hosts. The most promising and cost effective approach …
diagnosis in both human and canine hosts. The most promising and cost effective approach …
[HTML][HTML] Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB
Y Pérez-Pertejo, JM Escudero-Martínez… - International Journal for …, 2019 - Elsevier
Leishmania is the aethiological agent responsible for the visceral leishmaniasis, a serious
parasite-borne disease widely spread all over the World. The emergence of resistant strains …
parasite-borne disease widely spread all over the World. The emergence of resistant strains …
Amino acid containing amphiphilic hydrogelators with antibacterial and antiparasitic activities
Nanoscale self-assembly of peptide constructs represents a promising means to present
bioactive motifs to develop new functional materials. Here, we present a series of peptide …
bioactive motifs to develop new functional materials. Here, we present a series of peptide …
Development, Characterization, and In Vitro Biological Performance of Fluconazole‐Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis
Cutaneous leishmaniasis (CL) is a resistant form of leishmaniasis that is caused by a
parasite belonging to the genus Leishmania. FLU‐loaded microemulsions (MEs) were …
parasite belonging to the genus Leishmania. FLU‐loaded microemulsions (MEs) were …
Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations
Protozoan parasites of the genus Leishmania are the causative agents of leishmaniasis, a
spectrum of a disease that threatens public health worldwide. Although next-generation …
spectrum of a disease that threatens public health worldwide. Although next-generation …