Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

No medications prevent or reverse age-related cognitive decline. Physical activity (PA)
enhances memory in rodents, but findings are mixed in human studies. As a result, exercise …

Functional plasticity of the brain decreases during ageing causing marked deficits in
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein
misfolding disorders. The proteostasis network controls the health of the proteome by …

Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous
factors. Here, we review the role of sex hormones in the regulation of adult hippocampal …

Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and
forms an important barrier between the central nervous system and the blood. For unknown …

Memories become less precise and generalized over time as memory traces reorganize in
hippocampal–cortical networks. Increased time-dependent loss of memory precision is …

Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that
mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR …