Importance The conventional model of atherosclerosis presumes that the mass of
cholesterol within very low-density lipoprotein particles, low-density lipoprotein particles …

ContextComplications of atherosclerosis cause most morbidity and mortality in patients with
diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy …

Braunwald's Heart Disease remains your indispensable source for definitive, state-of-the-art
answers on every aspect of contemporary cardiology. Edited by Drs. Robert O. Bonow …

Background In patients with high cholesterol levels, lowering the cholesterol level reduces
the risk of coronary events, but the effect of lowering cholesterol levels in the majority of …

▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …

Background Although it is generally accepted that lowering elevated serum levels of low-
density lipoprotein (LDL) cholesterol in patients with coronary heart disease is beneficial …

Background In patients with coronary heart disease and a broad range of cholesterol levels,
cholesterol-lowering therapy reduces the risk of coronary events, but the effects on mortality …

ContextA frequently cited concept is that individual major risk factors for coronary heart
disease (CHD) are absent in many patients (perhaps> 50%) with CHD. However, prior …

For> 4 decades it has been recognized that elevated serum levels of high-density
lipoprotein cholesterol (HDL-C) are associated with reduced risk of cardiovascular disease …

ContextA low plasma level of high-density lipoprotein cholesterol (HDL-C) is a major risk
factor for coronary heart disease (CHD). A secondary prevention study, the Veterans Affairs …