Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Abstract Development of effective preventative interventions against SARS-CoV-2, the
etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein of SARS …

Background To address the unmet medical need for an effective prophylactic vaccine
against Ebola virus we assessed the safety and immunogenicity of three different two-dose …

Background Questions remain concerning the rapidity of immune responses and the
durability and safety of vaccines used to prevent Zaire Ebola virus disease. Methods We …

Human papillomavirus (HPV)-related malignancies are responsible for almost all cases of
cervical cancer in women, and over 50% of all cases of head and neck carcinoma …

Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …

Replication-incompetent adenoviral vectors have been under investigation as a platform to
carry a variety of transgenes, and express them as a basis for vaccine development. A …

Summary Background The Ebola epidemics in west Africa and the Democratic Republic of
the Congo highlight an urgent need for safe and effective vaccines to prevent Ebola virus …

Background Children account for a substantial proportion of cases and deaths from Ebola
virus disease. We aimed to assess the safety and immunogenicity of a two-dose …