Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …

Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is
more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop …

The development of pancreatic cancer requires the acquisition of oncogenic KRas mutations
and upregulation of growth factor signaling, but the relationship between these is not well …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

This review addresses oxidative stress and redox signaling in the pancreas under healthy
physiological conditions as well as in acute pancreatitis, chronic pancreatitis, pancreatic …

The contributions of the innate immune system to the development of pancreatic cancer are
still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells …

Background & Aims Pancreatic tumor cells release small extracellular vesicles (sEVs,
exosomes) that contain lipids and proteins, RNA, and DNA molecules that might promote …

The Golgi Complex is the central hub in the endomembrane system and serves not only as a
biosynthetic and processing center but also as a trafficking and sorting station for …