Objectives Efforts towards achieving durable resin–dentin bonds have been made for
decades, including the understanding of the mechanisms underlying hybrid layer (HL) …

Adhesive systems are resin-based materials that reach their final mechanical properties
through a polymerization process. Previous literature correlated the failure of the adhesive …

Objective Success in adhesive dentistry means long lasting restorations. However, there is
substantial evidence that this ideal objective is not always achieved. Current research in this …

Dentin can be described as a biological composite with collagen matrix embedded with
nanosized hydroxyapatite mineral crystallites. Matrix metalloproteinases (MMPs) and …

Objectives: The aim of this study was to explore the therapeutic opportunities of each step of
3-step etch-and-rinse adhesives. Methods: Etch-and-rinse adhesive systems are the oldest …

Objective Endogenous dentin collagenolytic enzymes, matrix metalloproteinases (MMPs)
and cysteine cathepsins, are responsible for the time-dependent hydrolysis of collagen …

OBJECTIVES: Contemporary adhesives lose their bond strength to dentin regardless of the
bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid …

In dentin bonding, contemporary dental adhesive systems rely on formation of the hybrid
layer, a biocomposite containing dentin collagen and polymerized resin adhesive. They are …

Several studies have shown that the dentin‐resin interface is unstable due to poor infiltration
of resin monomers into the demineralized dentin matrix. This phenomenon is related to the …

This review examines the fundamental processes responsible for the aging mechanisms
involved in the degradation of resin‐bonded interfaces, as well as some potential …