Type IV secretion in Gram‐negative and Gram‐positive bacteria
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …
Legionella and Coxiella effectors: strength in diversity and activity
J Qiu, ZQ Luo - Nature Reviews Microbiology, 2017 - nature.com
Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …
Resurrection of plant disease resistance proteins via helper NLR bioengineering
Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-
rich repeat (NLR) proteins that function as central nodes in immune receptor networks …
rich repeat (NLR) proteins that function as central nodes in immune receptor networks …
Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery
The type IV bacterial secretion system (SS) is reported to be one of the most ubiquitous SSs
in nature and can induce serious conditions by secreting type IV SS effectors (T4SEs) into …
in nature and can induce serious conditions by secreting type IV SS effectors (T4SEs) into …
[HTML][HTML] Leishmania lipophosphoglycan triggers caspase-11 and the non-canonical activation of the NLRP3 inflammasome
Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of
leishmaniasis, a disease that affects millions of people worldwide. We investigate the …
leishmaniasis, a disease that affects millions of people worldwide. We investigate the …
Mechanisms and consequences of noncanonical inflammasome-mediated pyroptosis
SS Wright, SO Vasudevan, VA Rathinam - Journal of molecular biology, 2022 - Elsevier
The noncanonical inflammasome, comprising inflammatory caspases 4, 5, or 11, monitors
the cytosol for bacterial lipopolysaccharide (LPS). Intracellular LPS-elicited autoproteolysis …
the cytosol for bacterial lipopolysaccharide (LPS). Intracellular LPS-elicited autoproteolysis …
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection
DM Cerqueira, MTR Gomes, ALN Silva… - PLoS …, 2018 - journals.plos.org
Innate immune response against Brucella abortus involves activation of Toll-like receptors
(TLRs) and NOD-like receptors (NLRs). Among the NLRs involved in the recognition of B …
(TLRs) and NOD-like receptors (NLRs). Among the NLRs involved in the recognition of B …
[HTML][HTML] Coxiella burnetii: international pathogen of mystery
AL Dragan, DE Voth - Microbes and infection, 2020 - Elsevier
Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This
unique pathogen has been historically challenging to study due to obstacles in genetically …
unique pathogen has been historically challenging to study due to obstacles in genetically …
Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18
Infection with Burkholderia pseudomallei or B. thailandensis triggers activation of the NLRP3
and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected …
and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected …
Right on Q: Genetics begin to Unravel Coxiella Burnetii host cell Interactions
CL Larson, E Martinez, PA Beare, B Jeffrey… - Future …, 2016 - Taylor & Francis
Invasion of macrophages and replication within an acidic and degradative phagolysosome-
like vacuole are essential for disease pathogenesis by Coxiella burnetii, the bacterial agent …
like vacuole are essential for disease pathogenesis by Coxiella burnetii, the bacterial agent …