Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by
generalized redness, scaling, itching and increased numbers of circulating atypical T …

Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

The canonical model of RB-mediated tumour suppression developed over the past 30 years
is based on the regulation of E2F transcription factors to restrict cell cycle progression …

Cell cycle progression is dependent on two major waves of gene expression. Early cell cycle
gene expression occurs during G1/S to generate factors required for DNA replication, while …

The CDKN2A gene is a tumor suppressor that encodes the CDK4/6 inhibitor p16ink4a. Loss
of this tumor suppressor contributes to the bypass of critical senescent signals and is …

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as
humans, plants, and insects. These proteins play a key role in regulating advancement of …