The effects of aging on glutamate neurotransmission in the brain is reviewed and evaluated.
Glutamate is the neurotransmitter in most of the excitatory synapses and appears to be …

Aging is characterized by the decline in many of the individual's capabilities. It has been
recognized that the brain undergoes structural and functional changes during aging that are …

The pathogenesis of Huntington's disease is still not completely understood. Several lines of
evidence from toxic/non‐transgenic animal models of Huntington's disease suggest that …

We assessed baseline and KCl‐stimulated glutamate release by using microdialysis in
freely moving young adult (7 months) and middle‐aged (17 months) transgenic mice …

Transient focal cerebral ischemia leads to extensive neuronal damage in cerebral cortex
and striatum. Normal functioning of glutamate transporters clears the synaptically released …

Infusion of the K+ channel blocker 4-aminopyridine in the hippocampus induces the release
of glutamate, as well as seizures and neurodegeneration. Since an imbalance between …

Background Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in
balancing excitatory and inhibitory signals in the brain. Increasing evidence suggest that …

Increasing evidence suggests that the detrimental effects of glucocorticoid (GC)
hypersecretion occur by activation of the hypothalamic-pituitary-adrenal (HPA) axis in …

The production of new neurons declines during adulthood and persists, although at very low
levels, in the aged hippocampus. Since neurogenesis in young adults has been related to …

Background Glutamate (Glu) and γ-aminobutyric acid (GABA) transporters play important
roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly …