The avian influenza A virus (AIV) is naturally prevalent in aquatic birds, infecting different
avian species and transmitting from birds to humans. Both AIVs, the H5N1 and H7N9 …

Host genetic variation has a major impact on infectious disease susceptibility. The study of
pathogen resistance genes, largely aided by mouse models, has significantly advanced our …

Background Although the burden of influenza is often discussed in the context of historical
pandemics and the threat of future pandemics, every year a substantial burden of lower …

There is a need to identify biomarkers predictive of severe dengue. Single-cohort
transcriptomics has not yielded generalizable results or parsimonious, predictive gene sets …

Highlights•Host immune responses play both protective and pathogenic roles in IAV and
CoV infections.•Synergy of adaptive and innate immunity is required for efficient control of …

Summary In December 2013, China reported the first human case of avian influenza A
(H10N8). A 73-year-old female with chronic diseases who had visited a live poultry market …

Background. The pandemic potential of avian influenza viruses A (H5N1) and A (H7N9)
remains an unresolved but critically important question. Methods. We compared the …

Background. We examined associations between single-nucleotide polymorphisms (SNPs)
of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese. Methods. A …

The role of host genetics in influenza infection is unclear despite decades of interest.
Confounding factors such as age, sex, ethnicity and environmental factors have made it …

The COVID-19 pandemic has affected people worldwide with varying clinical presentations
ranging from mild to severe or fatal, and studies have found that age, gender, and some …